After Komatsu got kidnapped, Toriko and Coco found themselves facing down by the Devil Serpent, the most dangerous beast in the cave with a capture level of 21. The Devil Serpent let out a cry so powerful that vibrates and destroyed the outer cave's entrance. Realising something is wrong, Tina who's outside the cave turned on her laptop to get information from the mini camera on Komatsu's helmet, only to find another Bishokuya kidnapped Komatsu intending to use him as bait to the other dangerous beasts.
The Devil Serpent proceed to attack Toriko and Coco using it's limbs and digestive fluids, the bishokuyas learned that it can regenerate itself at extraordinary speed and it don't mind spilling digestive fluids on it's own arm. Coco proposed to Toriko that he should hold off the Devil Serpant while Toriko should go and save Komatsu. Dismissing the idea, Toriko chose to fight with Coco since Coco can't see the shadow of death on the devilish snake. Toriko and Coco then showed their appetite demons which did not intimidate the serpent, they decided that Coco will limit it's movement while Toriko prepare his attack. However, the Devil Serpent managed to capture Coco and inject poison into the bishokuya's body, which Coco managed to counter it by creating antibodies on the spot and inject his own poison and antibodies into the Devil Serpent. With it's movement limited, Toriko went on and finished off the serpent with his 5 times Kugi Punch.
Later on, Komatsu and his kidnapper were seen facing another Devil Serpent in the caves.
Komatsu was targeted by the other Devil Python only in the anime, but in the manga, there were other animals going to Komatsu.
When Coco got injected by poison from the Devil Serpent, he didn't inject his own poison and antibodies into the Devil Sepent's body, in the manga he simply wait for the poison he shot earlier onto it's pit organs to take effect.
The scene where Toriko told Komatsu about how to use Toriko's fire crackers that he also said to use the ear plugs was added as a filler, but in the manga, Toriko forgot to tell Komatsu to cover his ears before using them.